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Quick Details of Flibanserin
Generic name: Flibanserin,Addyi
Brand name:: Addyi
Molecular Formula: C20H21F3N4O
Molecular Weight: 390.40
CAS Registry Number: 167933-07-5
Usages: A Medical Treatment for Female Hypoactive Sexual Desire Disorder
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What is Flibanserin?
Flibanserin, sold under the trade name, is a medication approved for the treatment of pre-menopausal women with hypoactive sexual desire disorder (HSDD). Flibanserin is the world’s first New drug for enhancing female sexuality. It can reduce the amount of 5-hydroxytryptamine which inhibits sexuality and improve sexual stimulant dopamine levels. It is already submitted to Food and Drug Administration of the United States for approval.

How Dose Flibanserin Work to Promote Female Libido?
Flibanserin can directly effect on the sexual pleasure control area of the female brain to restore female Flagging libido. By adjusting the aphrodisiac body system, Flibanserin Helps to restore the balance of sexual appetite suppression and exciting mechanism and lead to form a healthy sexual performance. The curative effect can be obtained a few weeks later. At the same time, the female Viagra also has a certain side effects. One-eighth of tested women appeared dizziness, fatigue and sleepiness.

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What are the dosages and cycles for flibanserin?
Indicated for premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not caused by a coexisting medical or psychiatric condition, problems within the relationship, or the effects of a medication or other drug substance
100 mg PO once daily at bedtime
Dosed at bedtime because administration during waking hours increases risks of hypotension, syncope, accidental injury, and CNS depression
Discontinued after 8 weeks if no improvement
Missed dose
If a dose is missed at bedtime, instruct the patient to take the next dose at bedtime on the next day
Instruct the patient to not double the next dose

Specifications Of Flibanserin

Items

Specifications

Appearance

white crystals or crystalline powder, has a faint, characteristic odor and bitter taste

Solubility

freely soluble in water and 95%ethanol, sparingly soluble in acetic anhydride and practically insoluble in diethyl ether

pH

3.5-4.5

Identification

1, red to dark purple color appears

with(III)iron chloride

2, light red precipitate formed with reinecke salt TS

3, UV spectrum meet the reference

4, solution (1%) responds to the qualitative test for chloride

Melting point

139-143 celcius degree

Clarity and color of solution

clear and colorless

Sulfate

0.048%max

Heavy metals

10ppm max

As

2ppm max

Organic acid(0.1M NaOH)

0.54ml max

Loss on drying

0.5% max

Residue on ignition

0.1%max

Residual organic Solvents (GC)

Xylol 0.217%max

Isopropanol 0.5%max

Related substances(HPLC)

Total impurity 1.5%max

Single impurity0.5%max

Free P-chloro phenoxy acetic 0.5%max

Count of bacteria

bacillus 1000/1g max

Mildew 100/1g max

Microzyme 100/1g max

Assay(C12H16CINO3.HCl, on dry basis)

99.70% min

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