Anti-estrogen steroids hormone Estriol for Female Gonadal Dysfunctions

Anti-estrogen steroids hormone Estriol for  Female Gonadal Dysfunctions

Description:
Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol. Estriol may play a role in the development of breast cancer, but based on in vitro research, does appear to act as an antagonist to the G-protein coupled estrogen receptor.  Though initial research suggested it could be used therapeutically as an estrogen, subsequent research failed to confirm this hypothesis.
Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.
Estradiol or oestradiol (American or British English usages), derives from estra-, Gk. οστρο? (oistros, literally meaning “verve or inspiration”) and -diol, a chemical name and suffix indicating that this form of steroid and sex hormone is a type of alcohol bearing two hydroxyl groups.
Estradiol is produced especially within the follicles of female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from progesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone). One principle pathway then converts progesterone to its 17-hydroxy-derivative, and then to androstenedione via sequential cytochrome P450-catalyzed oxidations.Action of aromatase on this dione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.

estriol-33

3.Application:
A chemical derivative of estradiol, ethinyl estradiol with maximum dosage 200 μg, is a major component of hormonal contraceptive devices. Combined forms of hormonal contraception contain ethinyl estradiol and a progestin, which both contribute to the inhibition of GnRH, LH, and FSH, which accounts for the ability of these birth control methods to prevent ovulation and thus prevent pregnancy. Other types of hormonal birth control contain only progestins and no ethinyl estradiol.

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Packing:
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Quality:
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Delivery:
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Semi-finished Injectable / Oral steroids:
Test prop———–100mg/ml 200mg/ml
Test enan———–250mg/ml 300mg/ml 400mg/ml 500mg/ml 600mg/ml
Test cyp————200mg/ml 250mg/ml 300mg/ml
Test Sustanon——-200mg/ml 250mg/ml 300mg/ml 400mg/ml
Deca—————-200mg/ml 250mg/ml
Equipoise———–200mg/ml 300mg/ml
Tren ace————100mg/ml 200mg/ml
Tren enan———–100mg/ml 200mg/ml
Dianabol————50mg/ml
Winstrol————50mg/ml
Masteron————100mg/ml 150mg/ml
Primobolone———100mg/ml
Supertest———–450mg/ml
Anomass ————400mg/ml
Ripex—————225mg/ml
Tritren————-180mg/ml
Tri Test————300mg/ml
Tri Deca————300mg/ml
Test Blend———-450mg/ml 500mg/ml
Nandro Test———225mg/ml
Mass—————-500mg/ml
Cut Depot———–400mg/ml
Tren Test———–225mg/ml
Nandro Test Depot———450mg/ml
Equi Test—————–450mg/ml
Rip Cut——————-175mg/ml
Tren Test Depot———–450mg/ml